Editor(s)
Dr. Pradip K. Bhowmik
Professor,
Department of Chemistry and Biochemistry, University of Nevada Las Vegas, Nevada, USA.

 

ISBN 978-93-89816-28-0 (Print)
ISBN 978-93-89816-29-7 (eBook)
DOI: 10.9734/bpi/tac/v4

 

This book covers key areas of chemistry and other related fields. The contributions by the authors include lignans; tetrahydrofuranoid; stobbe; chlorpyrifos pesticide; activated carbon; adsorption isotherms; thin films; XRD; solution casting technique; reactive oxygen species; 1,2,3-triazole; α-amino acid; oxazoline; 2D NMR; nitrile compound; cycloaddition; 5-substituted tetrazole; 1H-1,2,4-triazole; β-aminoalcohol; 2D heteronuclear NMR experiments; 1,2,3-triazole; 1,3-dipolar cycloaddition; 1H-15N correlation; carboxylic amino esters; N-alkylation; oxazolinic precursors; isoindoline-1,3-dione; N-alkylation; inorganic chemistry; chemistry education; 1,2,3-Triazole; 1,4-regioisomer; 1,5-regioisomer; phosphonic glycine analogs; NMR spectroscopy; chemical pathway; carboxylic amino esters; N-alkylation; pyrazole; N-alkylation; 2D NMR; inorganic chemistry etc. This book contains various materials suitable for students, researchers and academicians of this area.

 

Chapters


Unifying Mechanism for Plant Nutrients as Anticancer Agents: Electron Transfer, Reactive Oxygen Species and Oxidative Stress

Peter Kovacic, Ratnasamy Somanathan

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 1-22

Plants remain an important source of new drugs, new drug leads for making more effective drugs in the pharmaceutical industry. Plant based discovery resulted mainly in the development of anticancer and anti-infective agents providing new leads to the drug industry.

The present article focuses on a unifying mode of action for the nutrients, namely, resveratrol, epigallocatechin, polyene-ß-carotene, polyene lycopene, piperine, curcumin, genistein, luteolin, sulforaphane and pomegranate extract. The mechanism is based on electron transfer, reactive oxygen species and oxidative stress, which comprises an extension of earlier reports involving agents. Most of the compounds are precursors of electron transfer quinones, whereas others fit into the polyene category. The nutrients are better known as antioxidants. The dichotomy is addressed.   

Synthesis, Crystal Structure and IR Spectrum Studies of 2-(4-Methyl-2-Phenyl-4,5-Dihydrooxazol-4-ylmethyl)-Isoindole-1,3-Dione: New Perspectives

Khadim Dioukhane, Younas Aouine, Anouar Alami, Hassane Faraj, Abdelilah El Hallaoui

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 23-33

The organo-amino compound of title 2-(4-methyl-2-phenyl-4,5-dihydro-oxazol-4-ylmethyl)-isoindole-1,3-dione was synthesized by the mixture of (4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl-4-methylbenzenesulfonate and isoindoline-1,3-dione in N,N’-dimethylformamide with a yield of around 65%. The structural study of the compound, C19H16N2O3, is realized using single crystal X-Ray diffraction which shows that this compound crystallizes in the monoclinic system (P21/c, Z = 4) with the unit cell parameters: A = 14.3728 (13) Å, b = 9.6829 (10) Å, c = 11.8964 (12) Å and β = 107.384 (3). The refinement of the structure by the least-squares method with complete matrix leads to the following reliability factors R/Rw are 0.044/0.130. In the crystal, the molecules are linked together by hydrogen bonds and π…π interactions. The Infrared spectroscopic studies show the bands confirming the presence of the groups C=O, C-O, C-N, -CH3, -CH2 and =CH.

Systemic Assessment [SA] as a Tool to Assess Student Achievements in Inorganic Chemistry [Part-I]: Systemic Assessment Questions [SAQ,s] in Sodium Chemistry

A. F. M. Fahmy, J. J. Lagowski

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 34-53

The Systemic assessment [SA] strategy changes the assessment from traditional linear bothering exams to enjoyable puzzle games in the form of systemics. Systemic Assessment (SA) aims a more effective evaluation of the systemically oriented objectives articulated by the SATL model. SA raising the level of student’s academic achievements, increasing students learning outcomes, develops the ability to think systemically, assesses students’ higher-order thinking skills in which students are required to analyze, synthesize and evaluate, measures the students' ability to correlate between concepts with reduced working memory load. Systemic Assessment Questions (SAQ,s) are the building units of the systemic assessment. In this chapter, we use SA as a tool to assess student achievement in inorganic chemistry by taking sodium chemistry as a module. We use five types of systemic assessment questions, namely Systemic Sequencing Questions (SSQ’s) Systemic Synthesis Questions (SSynQ, s), Systemic Analysis Questions (SAnQ, s), Systemic Synthetic-Analytic Questions (SSyn-AQ, s) and complete Systemics (SCompQs). This chapter is suitable for students at the secondary level and could be used as an applicable model to assess students learning in sodium chemistry and other metals of the periodic table by changing the metal.

Structure Assignment of the Two Isomers of 2-(1H-1,2,3-Triazol-1-yl)-Glycine N-Protected by Spectroscopic Methods and by Chemical Pathway

Saïd Achamlale, Anouar Alami, Younas Aouine

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 54-63

We describes in this chapter, the assignment of the 1,4- and 1,5-regioisomer structures of N-protected 2-(1H-1,2,3-triazol-1-yl)-glycine derivatives on the basis of 1H NMR, IR and chemical pathway. A subsequent assignment of 1,4- and 1,5-regioisomer structures of biheterocyclic glycine derivatives and their phosphonic analogues were based on spectroscopic study in 1H NMR and 13C NMR.

Synthesis of Trans-3,4-Dibenzyl-2-Oxo-Tetrahydrofuran: Advanced Study

I. R. Jack, K. O. Orubite

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 64-68

Trans-3,4-dibenzyl-2-oxo-tetrahydrofuran (6) a substituted tetrahydrofuranoid lignan was synthesized in 70% yield via the Stobbe condensation between (1) benzaldehyde and (2) diethyl succinate. The structure was confirmed by the spectral data such as infra-red, proton magnetic resonance and mass spectrum. It has two similar but non equivalent aromatic groups which appeared at δ: 6.48 - 6.76 and 7.06-7.25 as multiplets.

Studies on the Adsorption Efficiency of Activated Carbon for Pesticide Vapour: Brief Overview

A. J. Hotton, J. T. Barminas, S. A. Osemeahon

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 69-77

Chlorpyrifos pesticides are endocrine disruptors, inhibitors of acetyl cholinesterase, used to control pests and prime contributors to indoor pollution in retail stores. Seven selected locally sourced adsorbents; Bone charcoal (BCA), corncobs, cotton seed, kokoli, sawdust, coconut shell (CSA) and Muruchi were evaluated. Only BCA and CSA shows peaks and were further examined at adsorptive temperatures of 283, 293, 303 and 313K. Adsorbents physical properties that is, micro pore surface area, total pore volume; micro pore volume, particle density and true density were measured and compared. Results from gas chromatography and surface characterization revealed that the adsorptive capacities of carbon (CSA) at various temperatures were higher than that of carbon (BCA). The plots of Langmuir and Freundlich Isotherms were well fitted by the measured adsorption data. The parameters of adsorption equation for both Langmuir and Freundlich were determined for the two adsorbents, which indicates increased values of adsorptive capacity at low temperature and decreases at high temperature. This study shows that activated carbon made from coconut shell has high surface area, micro porous structure, high degree of surface reactivity and higher heterogeneous properties that suggest it to be a better adsorbent sufficient for the adsorption of chlorpyrifos vapour in an indoor environment.

Mechanical Strength Analysis of Acrylic Films Using Acoustical Technique

A. R. Bansod, O. P. Chimankar, A. Gandhe

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 78-83

In order to improve the mechanical properties of acrylic films, Poly methyl-methacrylate (PMMA)/ Aluminum oxide (Al2O3) films are prepared following solution casting technique. The mechanical behavior of prepared films has been analyzed by employing Ultrasonic Pulse Echo method. The morphology of films is examined via XRD and SEM analysis. The synergetic effect is observed in films from obtained ultrasonic data. The elastic modulus is calculated and compared for better utilization.

Synthesis, Characterization and Antibacterial Activity of Diethyl 1-((4-Methyl-2-phenyl- 4,5-dihydrooxazol-4-yl)methyl)-1H-1,2,3-triazole-4,5-dicarboxylate: Advanced Study

Salaheddine Boukhssas, Sara Hajib, Younas Aouine, Anouar Alami, Hassane Faraj, Abdelilah El Hallaoui

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 84-92

The compound, diethyl 1-((4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)-1H-1,2,3-triazole-4,5-dicarboxylate 2, was synthesized in high yield, through 1,3-dipolar cycloaddition reaction of 4-(azidomethyl)-4-methyl-2-phenyl-4,5-dihydrooxazole and diethyl but-2-ynedioate in the absence of a solvent. The structure of the synthesized compound was established on the basis of NMR spectroscopy (1H, 13C), X-ray crystallography and MS data. The prepared compound was also tested in vitro for its antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli). The calculation of MBC/MIC ratio showed that this triazole derivative 2 had a bactericidal effect on the two strains tested.

Characterization and Antibacterial Activity of New α-Aminoester Derivative, Synthesized via N-Alkyaltion of Methyl α-Azido Glycinate

Oumaima Karai, Younas Aouine, Anouar Alami, Hassane Faraj, Abdelilah El Hallaoui

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 93-99

The amino ester derivative was synthesized via N-alkylation of methyl α-azido glycinate N-benzoylated 1 with methyl 2-amino-2-phenylacetate in methylene chloride and in presence of triethylamine as basic catalyst. The structure of the prepared compound was determined by spectroscopic methods: 1H-NMR, 13C-NMR, MS data, elemental analysis and confirmed by X-Ray diffraction. This compound was screened in vitro for its antibacterial activity against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Salmonella enteric). The synthesized compound showed an interesting inhibitory effect against all the strains tested.

Synthesis and Characterization of N-((tetrazol-5 yl)methyl)cyclohexanamine through 2D NMR Experiments: An Overview

Salaheddine Boukhssas, Sara Hajib, Younas Aouine, Anouar Alami, Hassane Faraj, Abdelilah El Hallaoui

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 100-108

Tetrazoles are an important class of nitrogen containing heterocycles with a wide range of medicinal and commercial applications. Tetrazolyl analogs of amino acids exhibit versatile biologic activity, and some of them are known pharmaceuticals. In addition, compounds of this type may be using in development of radiopharmaceuticals for positron emission tomography.

In continuation of our investigations in the tetrazolic amino acids, we described in this presentation the synthesis and characterization of some aminoalkyl and tetrazolic amino acid derivatives basing on different spectroscopic methods as NMR 2D.

A simple synthetic approach to N-((tetrazol-5-yl)methyl)cyclohexanamine in two steps starting from chloroacetonitrile and cyclohexylamine is reported. The synthesized compound was characterized by 2D NMR spectroscopy (1H, 13C) and elemental analysis data.

Synthesis and Characterization of 4-[(3,5-Dimethyl-1H-pyrazol-1-yl)Methyl]-4-Methyl-2-Phenyl-4,5-Dihydrooxazole

Sara Hajib, Younas Aouine, Anouar Alami, Hassane Faraj, Abdelilah El Hallaoui

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 109-115

The compound, 4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4-methyl-2-phenyl-4,5-dihydrooxazole 2 was prepared in high yield, through nucleophilic substitution reaction of the O-tosyloxazoline derivative 1, by heating in dimethyl sulfoxide (DMSO) and in presence of KOH as base. The structure of the synthesized compound was established on the basis of NMR spectroscopy (1H, 13C), MS data and elemental analysis.

Identification of the Regioselectivity of the Thermal Huisgen 1,3-Dipolar Cycloaddition Reaction between an Azide Derivative and a Synthetic Heterocyclic Alkyne, through a Comparative Study of NMR Spectral Data

Younas Aouine, Salaheddine Boukhssas, Anouar Alami, Hassane Faraj, Abdelilah El Hallaoui

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 116-124

The 1,3-dipolar cycloaddition reaction between 4-(azidomethyl)-4-methyl-2-phenyl-4,5-dihydrooxazole and 9-(prop-2-ynyl)-9H-carbazole, in toluene at reflux, leads to obtain two regioisomers with different proportions where the 1,4-regioisomer is generally more prominent than 1,5-regioisomer. The assignment of structures to 1,2,3-triazolic regioisomers was established in base of a comparative study of NMR spectral data (1H, 13C, 15N and 2D 1H-15N HMBC spectra) in addition to the elemental analysis and MS data.

Study of the Regioselectivity of the N-alkylation Reaction of 1H-1,2,4-Triazole with an O-tosyl Derivative, Using Two-Dimensional NMR Spectroscopy

Younas Aouine, Salaheddine Boukhssas, Anouar Alami, Hassane Faraj, Abdelilah El Hallaoui

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 125-132

The alkylation reaction of 1H-1,2,4-triazole with (4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl-4-methylbenzenesulfonate in presence of K2CO3 as base and a catalytic amount of tetrabutylammonium bromide in N,N’-dimethylformamide, followed by an oxazoline ring-opening reaction in an acidic medium, and protection of amine function, leads normally to obtain two regioisomers of N-protected β-aminoalcohols with prevalence of the N1-isomer. After purification by column chromatography of the crude reaction product, only a single product is obtained in 97% yield. Hence, there is need of its identification by spectroscopic study.

Synthesis, Characterization and Antibacterial Activity of Methyl N-[1-(benzoylamino)-2-methoxy-2-oxoethyl]Tryptophanate

Oumaima Karai, Younas Aouine, Anouar Alami, Hassane Faraj, Abdelilah El Hallaoui

Theory and Applications of Chemistry Vol. 4, , 7 March 2020, Page 133-141

The title compound, methyl N-[1-(benzoylamino)-2-methoxy-2-oxoethyl]tryptophanate 2, have been synthesized in high yield, via N-alkylation reaction of methyl 2-azido-2-benzamidoacetate with methyl 2-amino-3-(1H-indol-3-yl)propanoate in acetone, with the presence of diisopropylethylamine as a base. The structure of the prepared compound was characterized by 1H, 13C NMR in addition to MS, X-Ray diffraction data, and elemental analysis. This compound was tested in vitro for its antibacterial activity against Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus, and Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa and Salmonella enteric. The MIC values showed that the synthesized compound had a bactericidal effect against the strains tested.