Characterization and Antibacterial Activity of New α-Aminoester Derivative, Synthesized via N-Alkyaltion of Methyl α-Azido Glycinate
Theory and Applications of Chemistry Vol. 4,
Page 93-99
Abstract
The amino ester derivative was synthesized via N-alkylation of methyl α-azido glycinate N-benzoylated 1 with methyl 2-amino-2-phenylacetate in methylene chloride and in presence of triethylamine as basic catalyst. The structure of the prepared compound was determined by spectroscopic methods: 1H-NMR, 13C-NMR, MS data, elemental analysis and confirmed by X-Ray diffraction. This compound was screened in vitro for its antibacterial activity against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Salmonella enteric). The synthesized compound showed an interesting inhibitory effect against all the strains tested.
Keywords:
- Antibacterial activity
- carboxylic amino esters
- N-alkylation
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