A Wee Study on Behavioural, Organ Somatic Index and Histological Alterations of the Fresh Water Fish Pangasius sutchi in Response to Protection Studies, Exposed to Gamma Radiation Perceived by Genotoxic Assays: New Perspectives
Abstract
The aim of the present study was to evaluate radio-protective effect of Gymnema sylvestre and its active compound gymnemagenin against gamma radiation(60Co) in Pangasius sutchi. The fishes were treated with lowest concentration of amifostine (83.3 mg/kg of b.wt.), G. sylvestre plant-extract (25 mg/kg of b.wt.), and gymnemagenin (0.3 mg/kg of b.wt.) as intramuscular injection one hour prior to exposure of gamma radiation. The result revealed destructive histological alteration of irradiated fishes compared to pre-treatment group of amifostine, G. sylvestre, and gymnemagenin. Similarly, behavioural changes and organ somatic index also showed variations among the irradiated and pre-treatment groups which might reflect metabolic and physiologic disturbances under the effect of radiation. The pre-treatment of G. sylvestre showed similar result as compared to amifostine which indicates the existence of radio-protective properties in the plant.
