Kinetic Spectrophotmetric Method for Quantitation of Rizatriptan Benzoate in Pharmaceutical Formulations

S. Malini; Kalyan Raj; N. Suresha

S. Malini Department of Chemistry, Dayananda Sagar College of Engineering, Bangalore-560 078, India.
Kalyan Raj Department of Chemistry, BMS College of Engineering, Bangalore-560 019, India.
N. Suresha Department of Chemistry, Bangalore Institute of Technology, Bangalore-560 004, India.

Keywords: Kinetic determination, Chloramine-B, Rizatriptan benzoate, spectrophotometry, dosage forms, pharmaceutical analysis

Abstract

A simple, sensitive and accurate kinetic spectrophotometric method for the determination of Rizatriptan Benzoate in pure and dosage form is described. The method is based on spectrophotometrically monitored oxidation of the drug by a known excess of Chloramine-B in HCl medium using initial rate, fixed time and variable time method in HCl medium. The oxidized product exhibits a maximum absorption at 490nm. The apparent molar absorptivity and Sandells sensitivity values are in the range 2.97 x 10⁴to 0.0198 respectively. The proposed method has been successfully applied to the determination of RTB in commercial pharmaceutical formulations. Statistical comparison of the results with well-established reported method shows agreement in terms of precision and accuracy.