Prodrugs Design

Rafik Karaman

Rafik Karaman Department of Bioorganic Chemistry, Faculty of Pharmacy, Al-Quds University, P.O. Box 20002, Jerusalem, Palestine and Department of Sciences, University of Basilicata, Viadell�Ateneo Lucano 10, 85100, Potenza, Italy.

Keywords: Prodrugs, drugs, molecular orbital methods, molecular mechanics methods, dissolution

Abstract

Prodrug design can be used in the following cases: improving active drug solubility and consequently bioavailability, increasing permeability and absorption and modifying the drugs distribution profile. In the prodrug design, a computational approach consisting of calculations using Molecular Orbital (MO) and Molecular Mechanics (MM) methods and correlations between experimental and calculated values can be utilized.