A Critical Study of Retinoblastoma Case: Shall We Get a Paramagnetic Trend in Chemotherapy?

Alrxander A. Bukhvostov; Anton S. Dvornikov; Kirill V. Ermakov; Dmitry A. Kuznetsov

Alrxander A. Bukhvostov Interfaculty Cellular and Molecular Oncology Research Group, School of Medicine, N. I. Pirogoff Russian National Research Medical University, 1 Ostrovityanov St., Moscow 119997, Russian Federation.
Anton S. Dvornikov Interfaculty Cellular and Molecular Oncology Research Group, School of Medicine, N. I. Pirogoff Russian National Research Medical University, 1 Ostrovityanov St., Moscow 119997, Russian Federation.
Kirill V. Ermakov Interfaculty Cellular and Molecular Oncology Research Group, School of Medicine, N. I. Pirogoff Russian National Research Medical University, 1 Ostrovityanov St., Moscow 119997, Russian Federation.
Dmitry A. Kuznetsov Interfaculty Cellular and Molecular Oncology Research Group, School of Medicine, N. I. Pirogoff Russian National Research Medical University, 1 Ostrovityanov St., Moscow 119997, Russian Federation.

Keywords: Retinoblastoma, paramagnetics, chemotherapy

Abstract

Nuclear spin possessing isotopes (²⁵Mg, ⁴³Ca, ⁶⁷Zn) promote the marked magnetic isotope effects (MIE) on DNA Polymerase Beta (DNApolB) in ex vivo survived human retinoblastoma (RB) cells. In Aphidicolin chase experiment, the RB in situ catalytic activity of DNApolB has been selectively estimated as a function of MIE. A resulted enzyme function breakdown leads to a sharp decrease of cancer cell viability. This study a paramagnetic chemotherapy path is all about.