RNA Polymerase: The Master Executor

  • Vivek Pandey South Asian University, New Delhi 110021, India.
  • Yuba Raj Pokharel South Asian University, New Delhi 110021, India.
Keywords: RNA polymerase, core-conservation, transcription factors, transcriptional regulation, cancer

Abstract

RNA polymerases belong to a selected group of evolutionarily conserved proteins. Their role emerged with the coming of DNA molecules having more stability than the RNA molecules, which formed the RNA world before it. The chapter makes a detour through RNA polymerases working in a eukaryotic system and their prokaryotic counterparta special emphasis on their structural aspect and functional variation arising due to variation in structure. Further, the importance of various known transcription factors has been explained along with accessory transcription factors that serve as an essential regulator of RNAP activity. A mutation occurring in these proteins results in the aberration of polymerase activity that results in a plethora of diseases ranging from the developmental disorder, autoimmune diseases to cancers.

Published
2020-07-14
How to Cite
Pandey, V., & Pokharel, Y. R. (2020). RNA Polymerase: The Master Executor. Current Strategies in Biotechnology and Bioresource Technology Vol. 2, 43-60. Retrieved from https://stm1.bookpi.org/index.php/csbbt-v2/article/view/1735
Issue
Current Strategies in Biotechnology and Bioresource Technology Vol. 2
Section
Chapters