Study on Antioxidant Activity and Anticarcinogenic Properties of �Rumput mutiara� {Hedyotis corymbosa (L.) Lam.} and �Pohpohan� {Pilea trinervia (Roxb.) Wight}

  • Susi Endrini Faculty of Medicine and Health Sciences, Universitas Abdurrab, Jl. Riau Ujung Pekanbaru Riau Indonesia.
  • Himmi Marsiati Faculty of Medicine, Yarsi University, Cempaka Putih 10510, Jakarta, Indonesia.
Keywords: Microculture tetrazolium salt assay, Hedyotis corymbosa, Pilea trinervia, MCF-7, antioxidant activity, cytotoxic properties

Abstract

The research was conducted to determine the anticarcinogenic properties of rumput mutiara (Hedyotis corymbosa (L.) Lam) and pohpohan (Pilea trinervia (Roxb.) Wight), by the microculture tetrazolium salt (MTT) assay on the human breast carcinoma dependent-hormone (MCF-7) cell lines. The preliminary results showed that the rumput mutiara extract displayed the cytotoxic effects against MCF-7 with IC50-value of 22,67 g/ml. However, the pohpohan extract did not show the IC50-value against MCF-7 cell lines. The antioxidative activities of the extracts which could contribute to their cytotoxic properties were also studied. The rumput mutiara extract was found to have higher antioxidant activity compared with pohpohan extract. The strong cytotoxic properties of the rumput mutiara extract could be due to its high antioxidant activity. The combination effect of rumput mutiara and soursop were also studied.

Published
2020-06-20
How to Cite
Endrini, S., & Marsiati, H. (2020). Current Research Trends in Biological Science Vol. 2, 146-151. Retrieved from https://stm1.bookpi.org/index.php/crtbs-v2/article/view/1482
Issue
Current Research Trends in Biological Science Vol. 2
Section
Chapters